- Associate Professor of Biochemistry and Biophysics
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(646) 962-2784
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The Dittman laboratory is interested in synaptic function at the molecular and circuit levels. The lab is currently focused on three lines of research: spatial and temporal dynamics of synaptic proteins, the mechanisms underlying synaptic vesicle fusion and its modulation, and the impact of axonal ER on synapse function, axon integrity, and neurodegeneration.
- Professor of Biochemistry and Biophysics
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(212) 746-6557
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The Eliezer laboratory is primarily involved with the application of NMR spectroscopy to problems in non-native structural biology. This includes characterizing the location and extent of structure in and the intermolecular interactions of aggregation-competent partially unfolded states of proteins involved in neurodegenerative disease. Specific targets include Alzheimer's Disease and Parkinson's Disease related proteins.
- Professor of Biochemistry and Biophysics
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(212) 746-6362
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The Huang Laboratory deciphers the structural biochemistry of membrane-spanning signaling proteins—particularly seven-transmembrane GPCRs and single-pass receptors—to reveal the molecular logic of cross-membrane communication. Additionally, we engineer small-molecule fascin inhibitors that arrest tumor metastasis and invigorate intratumoral dendritic cells, opening new frontiers in precision cancer therapy.
- Professor of Biochemistry and Biophysics
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The Leschziner lab investigates the biological functions of macromolecular dynamics using cryo-electron microscopy combined with biophysical, biochemical, and cell biological methods. Their research centers on three main areas: Parkinson’s Disease mechanisms, microtubule-based intracellular transport, and chromatin structure and regulation.
- Associate Professor of Biochemistry and Biophysics
Phone:
(212) 746-3432
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The Levitz laboratory uses a variety of optical techniques to improve our understanding of synaptic signaling molecules with a focus on neurotransmitter-gated G protein-coupled receptors (GPCRs). The lab is particularly interested in probing GPCRs at the molecular, synaptic, and circuit levels to gain a more coherent and mechanistic view of their roles in physiology and neuropsychiatric disease.
- Assistant Professor of Biochemistry and Biophysics
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(646) 962-8708
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The Long lab studies the crosstalk between RNA and chromatin, with a focus in stem cell differentiation and cardiac development. This includes understanding the molecular mechanism of RNA-mediated regulation pathways by Polycomb group (PcG) and Trithorax group (TrxG) proteins, RNA-mediated epigenetic regulation of cardiac development, and how epitranscriptomics and epigenetics interconnect.
- Professor of Biochemistry and Biophysics
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(646) 962-2759
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The Maxfield laboratory studies basic cell biology of membrane traffic and its application to understanding and treating diseases. Current interests include cholesterol transport, control of lysosomal pH and extracellular degradation of large objects (e.g., amyloid, dead adipocytes, or deposits of lipoproteins) by macrophages. These studies are related to atherosclerosis, Alzheimer’s disease and a rare lysosomal storage disease (Niemann-Pick C disease).
- Professor of Biochemistry and Biophysics
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(212) 746-4982
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The McGraw laboratory uses quantitative optical microscopy to study insulin-regulated membrane trafficking. The main objectives of lab work are to characterize the GLUT4 trafficking pathway in the presence and absence of insulin, and to identify how the insulin-signal transduction regulates the movement of GLUT4 vesicles. In addition to studies of GLUT4 trafficking, we are also interested in more basic questions of membrane trafficking, specifically a more detailed understanding of the molecular mechanisms of clathrin-mediated internalization from the cell surface and the mechanisms for return of endocytosed proteins back to the plasma membrane.
- Professor of Biochemistry and Biophysics
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(646) 962-2476
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The Menon laboratory is interested in fundamental aspects of cellular membrane biogenesis. Lab work covers a number of areas concerned with lipid biosynthesis, propagation of the phospholipid bilayer of biological membranes, translocation (flip-flop) of lipids across bilayers, and intracellular lipid transport. The lab approaches these problems through biochemical, biophysical, genetic and chemical methods.
- Professor of Biochemistry and Biophysics
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(212) 746-6355
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We study ion channels in epithelial cells and their role in maintaining salt and water balance. Our focus is on Na channels (ENaC) and K channels (ROMK) in the kidney. We have investigated their functional properties and their regulation, especially by the adrenal steroid aldosterone.
- Professor of Biochemistry and Biophysics
- Professor of Biochemistry in Anesthesiology
- Tri-Institutional Professor
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(646) 962-2786
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The Ryan laboratory develops and applies quantitative methods to understand the molecular underpinnings of synapse function with a particular emphasis on the control of neurotransmitter release and the recycling of synaptic vesicles. The lab discovered that nerve terminals represent one of the critical loci of metabolic vulnerability in the brain which has led them to explore questions of how fuel availability and combustion is regulated to support synapse function.
- Assistant Professor of Biochemistry and Biophysics
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(646) 962-3047
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The Simon laboratory studies how individual neurons, unlike almost all other cell types in the body, survive for a lifetime. The lab asks how insults such as genetic mutation, injury or inflammation disrupt these survival programs to promote neurodegeneration. The lab also employs a range of molecular and biochemical techniques with the ultimate goals of understanding the molecular basis of neurodegeneration and identifying novel therapeutic targets.
- Associate Professor of Biochemistry and Biophysics
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The Teruel Lab studies diabetes and obesity signaling. Terminal cell differentiation is crucial for developing, maintaining, and regenerating tissues in all multi-cellular organisms. The overarching focus of the Teruel Lab is to understand how to control terminal differentiation in order to maintain a dynamic balance between progenitor and differentiated cells that ensures healthy tissue development and prevents disease. To tackle this problem, my lab developed a platform to understand adipogenesis (fat cell differentiation) and other differentiation processes based on automated live and fixed-cell microscopy and analysis tools. We simultaneously monitor and perturb cell cycle, circadian, signaling, and differentiation processes live in thousands of single cells, with the goal to understand how optimal timing of hormone stimuli and drug treatment can be used to maintain healthy fat and other tissues. To validate the relevance of our discoveries, we combine in vitro cell culture, organoid, and in vivo mouse models.