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Primary Faculty

Noah Dephoure
  • Assistant Professor of Biochemistry
  • Proteomics Core Director
Phone:
(646) 962-6232
Bio:
The Dephoure laboratory uses quantitative proteomics to globally monitor protein composition, abundance and post-translational modifications. The lab is trying to understand how signaling events such as phosphorylation regulate protein dynamics. The lab is also developing methods for identifying phosphorylation dependent changes in protein complex composition and protein subcellular localization. The hope is to leverage these methods to identify functional phosphorylation sites that impact cellular physiology and human disease.
Jeremy Dittman, M.D., Ph.D.
  • Associate Professor of Biochemistry
Phone:
(646) 962-2784
Bio:
The Dittman laboratory is interested in synaptic function at the molecular and circuit levels.  The lab is currently focused on three lines of research: spatial and temporal dynamics of synaptic proteins, the mechanisms underlying synaptic vesicle fusion and its modulation, and the impact of axonal ER on synapse function, axon integrity, and neurodegeneration.
David Eliezer, Ph.D.
  • Professor of Biochemistry
Phone:
(212) 746-6557
Bio:
The Eliezer laboratory is primarily involved with the application of NMR spectroscopy to problems in non-native structural biology. This includes characterizing the location and extent of structure in and the intermolecular interactions of aggregation-competent partially unfolded states of proteins involved in neurodegenerative disease. Specific targets include Alzheimer's Disease and Parkinson's Disease related proteins.
Joshua Levitz, Ph.D.
  • Associate Professor of Biochemistry
Phone:
(212) 746-3432
Bio:
The Levitz laboratory uses a variety of optical techniques to improve our understanding of synaptic signaling molecules with a focus on neurotransmitter-gated G protein-coupled receptors (GPCRs). The lab is particularly interested in probing GPCRs at the molecular, synaptic, and circuit levels to gain a more coherent and mechanistic view of their roles in physiology and neuropsychiatric disease.
Yicheng Long
  • Assistant Professor of Biochemistry
Phone:
(646) 962-8708
Bio:
The Long lab studies the crosstalk between RNA and chromatin, with a focus in stem cell differentiation and cardiac development. This includes understanding the molecular mechanism of RNA-mediated regulation pathways by Polycomb group (PcG) and Trithorax group (TrxG) proteins, RNA-mediated epigenetic regulation of cardiac development, and how epitranscriptomics and epigenetics interconnect.
Frederick Maxfield, Ph.D.
  • Professor of Biochemistry
Phone:
(646) 962-2759
Bio:
The Maxfield laboratory studies basic cell biology of membrane traffic and its application to understanding and treating diseases. Current interests include cholesterol transport, control of lysosomal pH and extracellular degradation of large objects (e.g., amyloid, dead adipocytes, or deposits of lipoproteins) by macrophages. These studies are related to atherosclerosis, Alzheimer’s disease and a rare lysosomal storage disease (Niemann-Pick C disease).
Timothy McGraw, Ph.D.
  • Professor of Biochemistry
Phone:
(212) 746-4982
Bio:
The McGraw laboratory uses quantitative optical microscopy to study insulin-regulated membrane trafficking. The main objectives of lab work are to characterize the GLUT4 trafficking pathway in the presence and absence of insulin, and to identify how the insulin-signal transduction regulates the movement of GLUT4 vesicles. In addition to studies of GLUT4 trafficking, we are also interested in more basic questions of membrane trafficking, specifically a more detailed understanding of the molecular mechanisms of clathrin-mediated internalization from the cell surface and the mechanisms for return of endocytosed proteins back to the plasma membrane.
Anant Menon, Ph.D.
  • Professor of Biochemistry
Phone:
(646) 962-2476
Bio:
The Menon laboratory is interested in fundamental aspects of cellular membrane biogenesis. Lab work covers a number of areas concerned with lipid biosynthesis, propagation of the phospholipid bilayer of biological membranes, translocation (flip-flop) of lipids across bilayers, and intracellular lipid transport. The lab approaches these problems through biochemical, biophysical, genetic and chemical methods.
Timothy Ryan, Ph.D.
  • Professor of Biochemistry
  • Professor of Biochemistry in Anesthesiology
Phone:
(646) 962-2786
Bio:
The Ryan laboratory develops and applies quantitative methods to understand the molecular underpinnings of synapse function with a particular emphasis on the control of neurotransmitter release and the recycling of synaptic vesicles. The lab discovered that nerve terminals represent one of the critical loci of metabolic vulnerability in the brain which has led them to explore questions of how fuel availability and combustion is regulated to support synapse function.
David J. Simon, Ph.D.
  • Assistant Professor of Biochemistry
Phone:
(646) 962-3047
Bio:
The Simon laboratory studies how individual neurons, unlike almost all other cell types in the body, survive for a lifetime. The lab asks how insults such as genetic mutation, injury or inflammation disrupt these survival programs to promote neurodegeneration. The lab also employs a range of molecular and biochemical techniques with the ultimate goals of understanding the molecular basis of neurodegeneration and identifying novel therapeutic targets.
Heidi Stuhlmann
  • Acting Chair of Biochemistry,
  • Professor & Acting Chair of Cell & Developmental Biology
Phone:
(212) 746-6156
Bio:
The Stuhlmann lab studies basic developmental biology of the the vascular system. A combination of molecular and genetic approaches including primary endothelial cells, embryonic stem cells, trophoblast stem cells, and loss- and gain-of-function mouse models are employed for these studies. A second research area is on the pathways and epigenetic mechanisms that drive placental development and disease such as preeclampsia. A recent focus has been on the impact of virus infections including ZIKA and SARS-CoV-2 on pregnancy and placentation.
Mary Teruel, Ph.D.
  • Associate Professor of Biochemistry
Bio:
The Teruel Lab studies diabetes and obesity signaling. Terminal cell differentiation is crucial for developing, maintaining, and regenerating tissues in all multi-cellular organisms. The overarching focus of the Teruel Lab is to understand how to control terminal differentiation in order to maintain a dynamic balance between progenitor and differentiated cells that ensures healthy tissue development and prevents disease. To tackle this problem, my lab developed a platform to understand adipogenesis (fat cell differentiation) and other differentiation processes based on automated live and fixed-cell microscopy and analysis tools. We simultaneously monitor and perturb cell cycle, circadian, signaling, and differentiation processes live in thousands of single cells, with the goal to understand how optimal timing of hormone stimuli and drug treatment can be used to maintain healthy fat and other tissues. To validate the relevance of our discoveries, we combine in vitro cell culture, organoid, and in vivo mouse models.

Weill Cornell Medicine Department of Biochemistry 1300 York Avenue,
Box #63 Room A-108
New York, NY 10065 Phone: (646) 962-2759