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The Maxfield laboratory studies basic cell biology of membrane traffic and its application to understanding and treating diseases. Current interests include cholesterol transport, control of lysosomal pH and extracellular degradation of large objects (e.g., amyloid, dead adipocytes, or deposits of lipoproteins) by macrophages. These studies are related to atherosclerosis, Alzheimer’s disease and a rare lysosomal storage disease (Niemann-Pick C disease).
