Department of Biochemistry

Frederick R. Maxfield, Ph.D.

Frederick Maxfield, Ph.D.
Professor of Biochemistry
Phone: 
(646) 962-2759
Email: 
frmaxfie@med.cornell.edu
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Lab Link
Research Area : 
Membrane Biology Molecular & Cellular Basis of Disease
Affiliated Graduate Program : 
BCMB Allied Program
Tri-Institutional Chemical Biology Program
Extracellular digestion of aggregated LDL illustration.
The current model of signaling required for the extracellular digestion of aggregated LDL (exophagy) is illustrated. This is a major focus of research in the Maxfield laboratory.

The Maxfield laboratory studies basic cell biology of membrane traffic and its application to understanding and treating diseases. Current interests include cholesterol transport, control of lysosomal pH and extracellular degradation of large objects (e.g., amyloid, dead adipocytes, or deposits of lipoproteins) by macrophages. These studies are related to atherosclerosis, Alzheimer’s disease and a rare lysosomal storage disease (Niemann-Pick C disease).

Lab Members

Lucy Funes

Research Technician

Jonathan Ma

Postdoctoral Associate

Santiago Solé-Domenech

Assistant Professor of Research

Noah Steinfeld

Postdoctoral Associate

Alvin Wang

Research Technician
Contact Us Directory

Weill Cornell Medicine Department of Biochemistry 1300 York Avenue,
Box #63 Room A-108 New York, NY 10065 Phone: (646) 962-2759