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Scientists Identify Protein that Promotes Brain Metastasis

Scientists Identify Protein that Promotes Brain Metastasis

A protein that breast, lung and other cancers use to promote their spread—or metastasis—to the brain, has been identified by a team led by Weill Cornell Medicine and New York-Presbyterian investigators. The protein, CEMIP, will now be a focus of efforts to predict, prevent and treat brain metastases, which are a frequent cause of cancer deaths.

In their study, published Nov. 4 in Nature Cell Biology, the scientists found...

Researchers Uncover Pathways Leading to Heart Defects in Genetic Syndrome

Researchers Uncover Pathways Leading to Heart Defects in Genetic Syndrome

Two molecular signaling pathways underlie the cardiac defects associated with one type of the inherited disorder Noonan syndrome (NS), researchers from Masonic Medical Research Institute, Beth Israel Deaconess Medical Center and Weill Cornell Medicine find in a new study. The investigators built the first patient-derived stem cell model of the RAF1 mutant form of NS to investigate the defect, a severe thickening of the...

Enzyme Digests Amyloid-Beta Associated with Alzheimer’s Disease

Enzyme Digests Amyloid-Beta Associated with Alzheimer’s Disease

An enzyme found in brain cells can break apart the precursors to plaques that accumulate in the organ and cause toxicity in Alzheimer’s disease, according to a new study led by Weill Cornell Medicine scientists.

The study, published Jan. 29 in the Proceedings of the National Academy of Sciences, illuminates where the enzyme, tripeptidyl peptidase 1 (TPP1), cuts these plaque precursors—formed by peptide fragments...

Biochemistry Post-Doc Honored with 2017 Tri-Institutional Breakout Award

Dr. Ghazaleh Ashrafi, a postdoctoral associate in biochemistry at Weill Cornell Medicine, has won a 2017 Tri-Institutional Breakout Award for Junior Investigators.

The awards, which honor outstanding postdoctoral investigators at Weill Cornell Medicine, Memorial Sloan Kettering and The Rockefeller University, are given annually to up to six promising postdoctoral trainees based on their research accomplishments, the impact...

Researchers Discover New Mechanism of Synapse Control

Researchers Discover New Mechanism of Synapse Control

A tiny tubular structure directly controls synapses, the junctions through which communication signals flow between nerve cells, according to a paper published Feb. 8 in Neuron. The research could eventually help scientists better understand and treat a variety of neurological diseases, including spastic paraplegia, which leads to stiffness, weakness and spasms in the legs, and amyotrophic lateral sclerosis (ALS), the...

Brain Cells, Like Muscle Cells, Mobilize Sugar in Response to Increased Activity

Brain Cells, Like Muscle Cells, Mobilize Sugar in Response to Increased Activity

New research provides insights into why the brain is so reliant on sugar to function. 

In a study published Jan. 19 in Neuron, a research team led by Weill Cornell Medicine investigators discovered that brain cells recruit a specific sugar, glucose, to fuel the transmission of electrical signals that enable people to think, breathe and walk. The findings suggest that the brain uses the same process to...

On the Fast Track

By Heather Salerno

Portraits by John Abbott

It's a rare, heartbreaking disease. Niemann-Pick Type C — which is often called "childhood Alzheimer's" because its adolescent victims deteriorate mentally as well as physically — lacks a cure or even a treatment. Patients most severely affected by the rare, hereditary, neurodegenerative disorder generally don't live beyond age 20. "We're also starting to realize that it's usually misdiagnosed," notes...

Graduate School Commencement Speaker Uses Small Discoveries to Bring Big Change

Graduate School Commencement Speaker Uses Small Discoveries to Bring Big Change

Dr. Igor Dikiy is just one small cog in the bigger machine that is the Weill Cornell Graduate School of Medical Sciences — or at least, that's how he sees it.

During his six years studying biochemistry in the graduate school, he was always more interested in looking at how smaller pieces added up to a big picture. Sometimes that meant shifting focus from a protein's specific involvement in Parkinson's disease to...

 Weill Cornell and Drug Maker UCB Strike Strategic Alliance

Weill Cornell and Drug Maker UCB Strike Strategic Alliance

Research Collaboration to Translate Scientific Breakthroughs into Innovative Treatments

Weill Cornell Medical College and drug maker UCB have teamed up to translate innovative Weill Cornell-led research in bone disorders, metabolic disease and genetics into next-generation treatments.

The...

Researchers Reveal Crucial Immune Fighter Role of the STING Protein

Researchers Reveal Crucial Immune Fighter Role of the STING Protein

Key Protein's Double Wing-Like Crystal Structure Captures Secreted Molecules from Invading Pathogens, Activating the Body's Powerful Immune Response

NEW YORK (June 14, 2012) — Researchers at Weill Cornell Medical College have unlocked the structure of a key protein that, when sensing certain viruses and bacteria, triggers the body's immediate immune response.

In the journal Molecular Cell, scientists describe the double wing-like crystal structure of this key...

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