News and Events

Uncovering Hidden Complexity in a Key Drug Target for Brain Disorders

Uncovering Hidden Complexity in a Key Drug Target for Brain Disorders

Metabotropic glutamate receptors, which are important but difficult drug targets, interact in surprisingly varied ways with their principal regulatory proteins, according to two new studies led by Weill Cornell Medicine investigators. The findings represent a big step forward in understanding these receptors and how they can be targeted effectively to potentially treat conditions such as epilepsy, depression, and anxiety disorders.

...

Stress Hormone Timing Creates a Different Kind of Obesity

Stress Hormone Timing Creates a Different Kind of Obesity

Obesity caused by disrupted stress-hormone rhythms is metabolically very different from obesity caused by a high-fat diet, according to a new preclinical study by Weill Cornell Medicine investigators. The researchers found in mice that glucocorticoid-rhythm disruption concentrates insulin resistance in skeletal muscle while preserving key insulin responses in fat tissue and liver. This allows fat tissue to continue storing lipids, while the liver remains largely protected from the fat...

Molecular Structures Provide Roadmap for Targeted Parkinson’s Disease Therapeutics

Molecular Structures Provide Roadmap for Targeted Parkinson’s Disease Therapeutics