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The Hao laboratory aims to understand why type 2 diabetes occurs and how it can be prevented. The lab focuses on the pancreatic beta-cells, which are the only cells that make and release insulin in response to an increase in glucose levels. Pancreatic islet dysfunction leading to insufficient glucose-stimulated insulin secretion triggers the clinical onset of diabetes. The lab also uses in vitro and in vivo systems to study the molecular mechanisms and pathophysiology of beta-cell dysfunction during type 2 diabetes development.
